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Clozapine N-oxide

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Catalog No：CL2075 CAS No.：34233-69-7 MDLNo： Formula：C18H19ClN4O MW：342.82

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	3-5days	$106.00	Visible after login	- +
10 mg	3-5days	$168.00	Visible after login	- +

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Product Overview

Product Name	Clozapine N-oxide
CAS	34233-69-7
Formula	C18H19ClN4O
MW	342.82
Appearance	Light yellow to yellow powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.

Related literature

DREADD-based synthetic control of chondrocyte calcium signaling in vitro.

PMID: 30908734 DOI: 10.1002/jor.24285

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Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice.

PMID: 30872749 PMCID: PMC6418145 DOI: 10.1038/s41598-019-41088-2

Read more

Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice.

PMID: 36892930 PMCID: PMC9998087 DOI: 10.7554/eLife.84740

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