Home > Category > Signaling Pathways > PROTAC > Ligands for E3 Ligase > Pomalidomide (Synonyms: CC-4047;3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide; 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione)

Pomalidomide (Synonyms: CC-4047;3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide; 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione)

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Catalog No:CL2201 CAS No.:19171-19-8 MDLNo: Formula:C13H11N3O4 MW:273.24
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Product Overview
Product Name Pomalidomide (Synonyms: CC-4047;3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide; 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione)
CAS19171-19-8
FormulaC13H11N3O4
MW273.24
AppearanceYellow powder
Storage condition Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Product details

Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN). Pomalidomide promotes apoptosis and cell cycle arrest.
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