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Upadacitinib hemihydrate

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Catalog No:CL2247A CAS No.:2050057-56-0 MDLNo: Formula:C34H40F6N12O3 MW:778.75
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Product Overview
Product Name Upadacitinib hemihydrate
CAS2050057-56-0
FormulaC34H40F6N12O3
MW778.75
Product details

Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.

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