Product Name | Upadacitinib hemihydrate |
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CAS | 2050057-56-0 |
Formula | C34H40F6N12O3 |
MW | 778.75 |
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Product Name | Upadacitinib hemihydrate |
---|---|
CAS | 2050057-56-0 |
Formula | C34H40F6N12O3 |
MW | 778.75 |
Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.