Apricitabine | SPD754 | AVX754

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	$168.00	Visible after login	- +
5 mg	3-5days	$388.00	Visible after login	- +

Product Overview

Product Name	Apricitabine (Synonyms: SPD754; AVX754)
CAS	160707-69-7
Formula	C8H11N3O3S
MW	229.26

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Product details

Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.
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Related literature

Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2'-deoxy-3'-oxa-4'-thiocytidine.

PMID: 10428900 PMCID: PMC89378 DOI: 10.1128/AAC.43.8.1835

History

CL2256

Apricitabine (Synonyms: SPD754; AVX754)

160707-69-7 98+%