Tandutinib | MLN518 | CT53518

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Tandutinib \| MLN518 \| CT53518
CAS	387867-13-2
Formula	C₃₁H₄₂N₆O₄
MW	562.7
Appearance	Yellowish powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR, and KDR.

Related literature

CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML).

PMID: 12124172 DOI: 10.1016/s1535-6108(02)00070-3

Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis.

PMID: 15242881 DOI: 10.1182/blood-2003-05-1669

The FLT3 inhibitor tandutinib (formerly MLN518) has sequence-independent synergistic effects with cytarabine and daunorubicin.

PMID: 19625780 DOI: 10.4161/cc.8.16.9355

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History

CL2273

Tandutinib | MLN518 | CT53518

387867-13-2 95%

Tandutinib | MLN518 | CT53518

Chemical safety data sheet(MSDS)