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Ponatinib (Synonyms: AP24534)

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Catalog No：CL2363 CAS No.：943319-70-8 MDLNo： Formula：C29H27F3N6O MW：532.56

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	In-stock	$56.00	Visible after login	- +
10 mg	In-stock	$88.00	Visible after login	- +

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Product Overview

Product Name	Ponatinib (Synonyms: AP24534)
CAS	943319-70-8
Formula	C29H27F3N6O
MW	532.56
Melting point	>160 °C
Appearance	Light yellow to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC₅₀s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
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Related literature

Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies.

PMID: 21482694 PMCID: PMC3236248 DOI: 10.1158/1535-7163.MCT-10-1044

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AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance.

PMID: 19878872 PMCID: PMC2804470 DOI: 10.1016/j.ccr.2009.09.028

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Hes1 upregulation contributes to the development of FIP1L1-PDGRA-positive leukemia in blast crisis.

PMID: 24486648 DOI: 10.1016/j.exphem.2014.01.009

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