Product Name | Midostaurin | PKC412 | CGP 41231 | CGP 41251 |
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CAS | 120685-11-2 |
Formula | C35H30N4O4 |
MW | 570.64 |
Appearance | White to yellow powder |
Storage condition | -20°C, sealed storage, away from moisture |
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Product Name | Midostaurin | PKC412 | CGP 41231 | CGP 41251 |
---|---|
CAS | 120685-11-2 |
Formula | C35H30N4O4 |
MW | 570.64 |
Appearance | White to yellow powder |
Storage condition | -20°C, sealed storage, away from moisture |
PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.
PMID: 10454207 DOI: 10.1016/s0163-7258(99)00005-4
PMID: 15890550 DOI: 10.1016/j.niox.2005.04.001
ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412.
PMID: 23131561 DOI: 10.1016/j.bbrc.2012.10.087
PMID: 23539538 PMCID: PMC3762103 DOI: 10.3324/haematol.2012.079202