LY404039 | LY2140023 | (1R,4S,5S,6S)-4-氨基-2-硫杂双环[3.1.0]己烷-4,6-二甲酸 2,2-二氧化物

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Product Overview

Product Name	LY404039 \| LY2140023
CAS	635318-11-5
Formula	C₇H₉NO₆S
MW	235.21
Appearance	White to gray powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

LY404039 is a potent, selective and orally active mGluR2 and mGluR3 agonist with K_is of 149 nM and 92 nM for recombinant human mGluR2 and mGluR3, respectively. LY404039 shows >100-fold selectivity for mGluR2/3 over other receptors/transproters. LY404039 has antipsychotic and anxiolytic effects.

Related literature

Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039).

PMID: 17204749 DOI: 10.1124/jpet.106.110809

In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonistLY404039 in animal models of psychiatric disorders.

PMID: 17384937 DOI: 10.1007/s00213-007-0758-3

An agonist at glutamate and dopamine D2 receptors, LY404039.

PMID: 22884896 DOI: 10.1016/j.neuropharm.2012.07.001

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History

CL2391

LY404039 | LY2140023

635318-11-5 98+%