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Go 6983

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Catalog No：CL2440 CAS No.：133053-19-7 MDLNo： Formula：C26H26N4O3 MW：442.51

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	In-stock	$150.00	Visible after login	- +
10 mg	In-stock	$225.00	Visible after login	- +
25 mg	3-5days	$380.00	Visible after login	- +

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Product Overview

Product Name	Go 6983
CAS	133053-19-7
Formula	C26H26N4O3
MW	442.51
Appearance	Pink to red powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Go 6983 (also known as GOE-6983; Go-6983; GOE6983; Go6983) is a novel and potent pan-PKC (protein kinase C) inhibitor with potential anticancer and cardioprotective activity. It inhibits PKCα, PKCβ, PKCγ and PKCδ with IC50s of 7 nM, 7 nM, 6 nM and 10 nM, respectively. Go 6983 shows less potency against PKCζ and is inactive on PKCμ. GO6893 displays cardioprotective properties and can reduce polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. When tested with MCF-7 and T47D cells, Go 6983 showed reversible effect on the down-regulation of PKCαand PKCδ induced by PKC activator PDBu, while decreased the expression of PKCη which up-regulated by PDBu.

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CL2440

Go 6983

133053-19-7 98+%