Home > Category > Signaling Pathways > Protein Tyrosine Kinase/RTK > EGFR > Gefitinib (Synonyms: ZD1839; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine)

Gefitinib (Synonyms: ZD1839; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine)

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Catalog No：CL2457 CAS No.：184475-35-2 MDLNo： Formula：C22H24ClFN4O3 MW：446.90

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
50 mg	In-stock	$38.00	Visible after login	- +
100 mg	3-5days	$66.00	Visible after login	- +

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Product Overview

Product Name	Gefitinib (Synonyms: ZD1839; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine)
CAS	184475-35-2
Formula	C22H24ClFN4O3
MW	446.90
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy and cell apoptosis, which can be used for cancer related research, such as Lung cancer and breast cancer.

Related literature

Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII.

PMID: 16189524 PMCID: PMC2361662 DOI: 10.1038/sj.bjc.6602793

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ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy.

PMID: 12384534

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Gefitinib inhibits M2-like polarization of tumor-associated macrophages in Lewis lung cancer by targeting the STAT6 signaling pathway. Acta Pharmacol Sin.

PMID: 29022575 PMCID: PMC5672074 DOI: 10.1038/aps.2017.124

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Gefitinib prevents cancer progression in mice expressing the activated rat HER2/neu.

PMID: 18076070 DOI: 10.1002/ijc.23231

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Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics.

PMID: 18076070 DOI: 10.1002/ijc.23231

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Gefitinib sensitization of cisplatin-resistant wild-type EGFR non-small cell lung cancer cells.

PMID: 32342201 PMCID: PMC7185832 DOI: 10.1007/s00432-020-03228-4

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Gefitinib (Synonyms: ZD1839; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine)

184475-35-2 98+%