Olverembatinib | GZD824 | HQP1351

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
10 mg	3-5days	$125.00	Visible after login	- +
25 mg	3-5days	$245.00	Visible after login	- +
50 mg	3-5days	$365.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

10 mg

3-5days

$125.00

Visible after login

- +

25 mg

3-5days

$245.00

Visible after login

- +

50 mg

3-5days

$365.00

Visible after login

- +

Product Overview

Product Name	Olverembatinib (Synonyms: GZD824; HQP1351)
CAS	1257628-77-5
Formula	C29H27F3N6O
MW	532.56
Appearance	Off-white to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

GZD824 potently suppressed proliferation of Bcr-Abl-positive K562 and Ku812 human CML cells with IC(50) values of 0.2 and 0.13 nM, respectively. It also displayed good oral bioavailability (48.7%), a reasonable half-life (10.6 h), and promising in vivo antitumor efficacy.

GZD824 induced tumor regression in mouse xenograft tumor models driven by Bcr-Abl(WT) or the mutants and significantly improved the survival of mice bearing an allograft leukemia model with Ba/F3 cells harboring Bcr-Abl(T315I).

Related literature

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