Azacitidine | 5-Azacytidine | 5-AzaC | Ladakamycin | CAS 320-67-2

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Product Overview

Product Name	5-Azacytidine (Synonyms: Azacitidine; 5-AzaC; Ladakamycin)
CAS	320-67-2
Formula	C8H12N4O5
MW	244.20
Appearance	White to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy.

Related literature

Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidineand 5-aza-2'-deoxycytidine.

PMID: 6173384

5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy.

PMID: 12154409 DOI: 10.1038/sj.onc.1205699

Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia.

PMID: 5487063

5-Azacytidine and Resveratrol Enhance Chondrogenic Differentiation of Metabolic Syndrome-Derived Mesenchymal Stem Cells by Modulating Autophagy.

PMID: 31214275 PMCID: PMC6535830 DOI: 10.1155/2019/1523140

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History

CL2719