RMC-7977

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
2 mg	3-5days	$346.00	Visible after login	- +
5 mg	3-5days	$556.00	Visible after login	- +

Product Overview

Product Name	RMC-7977
CAS	2765082-12-8
Formula	C47H60N8O6S
MW	865.09
Appearance	White to light yellow powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

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Product details

RMC-7977 is a potent, reversible, tri-complex oral inhibitor that selectively targets active (GTP-bound) forms of KRAS, HRAS, and NRAS, which exhibits broad-spectrum activity against both mutant and wild-type variants (a RAS^MULTI (ON) inhibitor). It also exhibits significant anti-tumor efficacy in pancreatic ductal adenocarcinoma (PDAC).

Related literature

RAS MULTI (ON) inhibitor RMC-7977 targets oncogenic RAS mutations and overcomes RAS/MAPK-mediated resistance to FLT3 inhibitors in AML models

https://doi.org/10.1182/blood-2023-178397