936091-14-4 | Tg 101209

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	TG101209
CAS	936091-14-4
Formula	C26H35N7O2S
MW	509.67
Appearance	White to gray powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET (c-RET) with IC50 of 25 nM and 17 nM in cell-free assays, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.

Related literature

TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations.

PMID: 17541402 DOI: 10.1038/sj.leu.2404750

A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera

PMID: 19772888 DOI: 10.1016/j.exphem.2009.08.008

Inhibition of JAK2 signaling by TG101209 enhances radiotherapy in lung cancer models.

PMID: 21325979 PMCID: PMC3104103 DOI: 10.1097/JTO.0b013e31820d9d11

Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase

PMID: 22384256 PMCID: PMC3288102 DOI: 10.1371/journal.pone.0032451

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