BIO (GSK-3 Inhibitor IX | 6-bromoindirubin-3-oxime | 6-Bromoindirubin-3'-oxime | MLS 2052 | (2'Z,3'E)-6-Bromoindirubin-3'-oxime | 6-BIO

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
2 mg	3-5days	$108.00	Visible after login	- +
5 mg	3-5days	$168.00	Visible after login	- +
10 mg	3-5days	$266.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

2 mg

3-5days

$108.00

Visible after login

- +

5 mg

3-5days

$168.00

Visible after login

- +

10 mg

3-5days

$266.00

Visible after login

- +

Product Overview

Product Name	BIO (GSK-3 Inhibitor IX \| 6-bromoindirubin-3-oxime \| 6-Bromoindirubin-3'-oxime \| MLS 2052 \| (2'Z,3'E)-6-Bromoindirubin-3'-oxime \| 6-BIO \| 6BIO
CAS	667463-62-9
Formula	C16 H10BrN3O2
MW	356.17
Appearance	Brown to red powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC₅₀s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively.

Related literature

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor.

PMID: 14702635 DOI: 10.1038/nm979

The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes.

PMID: 16984885 DOI: 10.1016/j.chembiol.2006.08.004

6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells.

PMID: 21610112 PMCID: PMC3107399 DOI: 10.1158/0008-5472.CAN-10-3852

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History

CL2889

BIO (GSK-3 Inhibitor IX | 6-bromoindirubin-3-oxime | 6-Bromoindirubin-3'-oxime | MLS 2052 | (2'Z,3'E)-6-Bromoindirubin-3'-oxime | 6-BIO | 6BIO

667463-62-9 99+%