Tolcapone | Ro 40-7592

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Price(USD)

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Quantity

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Product Overview

Product Name	Tolcapone \| Ro 40-7592
CAS	134308-13-7
Formula	C14H11NO5
MW	273.24
Appearance	Light yellow to yellow powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.

Related literature

Catechol-O-methyltransferase: variation in enzyme activity and inhibition by entacapone and tolcapone.

PMID: 9681662 DOI: 10.1007/s002280050448

Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity.

PMID: 20150427 PMCID: PMC2865316 DOI: 10.1074/jbc.M109.080390

Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma

PMID: 28429453 PMCID: PMC5463066 DOI: 10.1002/cam4.1065

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History

CL2904

Tolcapone | Ro 40-7592

134308-13-7 98+%

Tolcapone | Ro 40-7592

Chemical safety data sheet(MSDS)