Aliskiren Hemifumarate (Synonyms: CGP 60536 hemifumarate; CGP60536B hemifumarate; SPP 100 hemifumarate)； CAS: 173334-58-2

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Product Overview

Product Name	Aliskiren Hemifumarate (Synonyms: CGP 60536 hemifumarate; CGP60536B hemifumarate; SPP 100 hemifumarate)
CAS	173334-58-2
Formula	C34H57N3O10
MW	667.83
MDL	MFCD10566724
Appearance	White to off-white powder
Storage condition	4°C, sealed storage, away from moisture

Product details

Aliskiren hemifumarate (CGP 60536; CGP60536B; SPP 100) is an orally active, selective renin inhibitor with an IC50 of 1.5 nM. It is utilized in research pertaining to hypertension, cardiovascular diseases, and cancer cachexia.As a direct renin inhibitor, aliskiren targets the renin-angiotensin-aldosterone system (RAAS), a key pathway in blood pressure regulation. Its role in hypertension management is significant, offering an alternative to traditional antihypertensive medications. Additionally, aliskiren's potential impact on cardiovascular health and cancer cachexia is under investigation, highlighting its broad research applications.

Related literature

Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor.

https://doi.org/10.1021/ml300168e

Aliskiren inhibits prorenin-induced human aortic smooth muscle cell migration.

PMID: 25070349 DOI: 10.1177/1470320314528364

Sorry, no related items

History

CL3027A

Aliskiren Hemifumarate (Synonyms: CGP 60536 hemifumarate; CGP60536B hemifumarate; SPP 100 hemifumarate)

173334-58-2 98+%

Aliskiren Hemifumarate (Synonyms: CGP 60536 hemifumarate; CGP60536B hemifumarate; SPP 100 hemifumarate)

Chemical safety data sheet(MSDS)