NVP-TAE 684 | TAE 684 | CAS 761439-42-3

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	NVP-TAE 684 \| TAE 684
CAS	761439-42-3
Formula	C30H40ClN7O3S
MW	614.20
Appearance	Light yellow to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

NVP-TAE 684 (TAE 684) is a highly potent and selective ALK inhibitor, which blocks the growth of ALCL-derived and ALK-dependent cell lines with IC₅₀ values between 2 and 10 nM.

Related literature

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

PMID: 17185414 PMCID: PMC1765448 DOI: 10.1073/pnas.0609412103

Therapeutic strategies to overcome PF-02341066 resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.

PMID: 21502504 PMCID: PMC3088626 DOI: 10.1073/pnas.1019559108

Activating ALK mutations found in neuroblastoma are inhibited by PF-02341066 and NVP-TAE684.

PMID: 21838707 DOI: 10.1042/BJ20101796

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History

NVP-TAE 684 | TAE 684

761439-42-3 98+%

NVP-TAE 684 | TAE 684

Chemical safety data sheet(MSDS)