buy Istiratumab | Istiratumab supplier | purchase Istiratumab | Istiratumab cost | Istiratumab manufacturer | order Istiratumab | Istiratumab distributor; CAS: 1509928-04-4

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Anti-Human IGF1RxHer3 Bispecific Antibody (Istiratumab; MM 141; MM-005)
CAS	1509928-04-4

Product details

Istiratumab, a bispecific mAb against IGF-1R and ErbB3, promotes receptor degradation via proteasomes, inhibiting AKT in pancreatic cancer cells and blocking PI3K/MAPK in ovarian cancer. It enhances chemo efficacy, potentiating paclitaxel, cisplatin, and doxorubicin in preclinical studies.

Related literature

Randomized, double-blind, placebo-controlled phase II study of istiratumab (MM-141) plus nab-paclitaxel and gemcitabine versus nab-paclitaxel and gemcitabine in front-line metastatic pancreatic cancer (CARRIE).

PMID: 31912800 DOI: 10.1016/j.annonc.2019.09.004

Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer.

PMID: 29549161 DOI: 10.1158/1078-0432.CCR-17-2262

Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer.

PMID: 31728045 PMCID: PMC6856132 DOI: 10.1038/s41598-019-53322-y

Sorry, no related items

History

CLA1389

Anti-Human IGF1RxHer3 Bispecific Antibody (Istiratumab; MM 141; MM-005)

1509928-04-4 95+%