Rocaglamide | Roc-A | MG-002

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	$486.00	Visible after login	- +
5 mg	3-5days	$4036.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

3-5days

$486.00

Visible after login

- +

5 mg

3-5days

$4036.00

Visible after login

- +

Product Overview

Product Name	Rocaglamide \| Roc-A \| MG-002
CAS	84573-16-0
Formula	C29H31NO7
MW	505.56
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia.

Related literature

Tight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state.

PMID: 23869022 PMCID: PMC3959726 DOI: 10.1126/science.1238303

Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation.

PMID: 25333816 PMCID: PMC4237083 DOI: 10.3892/mmr.2014.2718

Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells.

PMID: 25333816 PMCID: PMC4237083 DOI: 10.3892/mmr.2014.2718

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History

HL1450

Rocaglamide | Roc-A | MG-002

84573-16-0 98+%

Rocaglamide | Roc-A | MG-002

Chemical safety data sheet(MSDS)