Product Name | PD184352(CI-1040) |
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CAS | 212631-79-3 |
Formula | C17H14ClF2 IN2O2 |
MW | 478.66 |
Appearance | White to off-white powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Size | Availability | Price(USD) | VIP Price (USD) | Quantity |
---|---|---|---|---|
5 mg | 3-5days | $100.00 | Visible after login | |
10 mg | 3-5days | $160.00 | Visible after login | |
25 mg | 3-5days | $290.00 | Visible after login |
Product Name | PD184352(CI-1040) |
---|---|
CAS | 212631-79-3 |
Formula | C17H14ClF2 IN2O2 |
MW | 478.66 |
Appearance | White to off-white powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
PD184352 (PD-184352; CI-1040), an analog of benzhydroxamate, is an orally bioactive, specific, allosteric/non-ATP competitive MEK1/2 inhibitor with potential anticancer activity. In cell-based assays, it inhibits MEK1/2 with IC50 values of 17 nM and exhibits a 100-fold preference for MEK1/2 over MEK5. In mouse xenograft models, it exhibits strong in vitro anti-proliferative activity and significant in vivo antitumor efficacy.