buy Y-27632 2HCl| Y-27632 2HCl supplier | purchase Y-27632 2HCl | Y-27632 2HCl cost | Y-27632 2HCl manufacturer

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	In-stock	$106.00	Visible after login	- +
10 mg	In-stock	$136.00	Visible after login	- +
25 mg	In-stock	$236.00	Visible after login	- +
50 mg	In-stock	$426.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

5 mg

In-stock

$106.00

Visible after login

- +

10 mg

In-stock

$136.00

Visible after login

- +

25 mg

In-stock

$236.00

Visible after login

- +

50 mg

In-stock

$426.00

Visible after login

- +

Product Overview

Product Name	Y-27632 Dihydrochloride (Synonyms: Y-27632 2HCl ; trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride)
CAS	129830-38-2
Formula	C14H21N3O.2HCl
MW	320.26 \| 247.34(free)
MDL	MFCD03490488
Appearance	White to off-white powder
Storage condition	4°C, sealed storage, away from moisture

Product details

The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 2HClis a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM. One-hour treatment with 10 µMY-27632 2HCl blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages.
buy Y-27632 2HCl | Y-27632 2HCl supplier | purchase Y-27632 2HCl | Y-27632 2HCl cost | Y-27632 2HCl manufacturer | order Y-27632 2HCl | Y-27632 2HCl distributor

Related literature

A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats

Inan S, et al. Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.

Analysis of Motor Neurons Differentiated from Human Induced Pluripotent Stem Cells for the Use in Cell-Based Botulinum Neurotoxin Activity Assays[J].

https://doi.org/10.3390/toxins12050276

Galectin‐3 exacerbates ox‐LDL‐mediated endothelial injury by inducing inflammation via integrin β1‐RhoA‐JNK signaling activation[J].

https://doi.org/10.1002/jcp.27910