Ro 61-8048

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	RO 61-8048
CAS	199666-03-0
Formula	C17H15N3O6S2
MW	421.45
Appearance	Light yellow to yellow powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Ro61-8048 is a potent Kynurenine hydroxylase inhibitor (Ki = 4.8 nM, IC50 = 37 nM). Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia. Ro 61-8048 may be potentially useful for the treatment of dyskinesias. Ro 61-8048 could be a new avenue to reduce neuronal loss in brain ischemia.

Related literature

Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.

PMID: 9435907 DOI: 10.1021/jm970467t

Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl) thiazol-2yl]-benzenesulfonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase

https://doi.org/10.1016/S0028-3908(99)00048-9

Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant.

PMID: 18353306 DOI: 10.1016/j.ejphar.2008.02.052

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History

CL1216

RO 61-8048

199666-03-0 98+%

Chemical safety data sheet(MSDS)