A-1155463

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	$76.00	Visible after login	- +
2 mg	3-5days	$109.00	Visible after login	- +
5 mg	3-5days	$156.00	Visible after login	- +
10 mg	3-5days	$216.00	Visible after login	- +
25 mg	3-5days	$376.00	Visible after login	- +
50 mg	3-5days	$586.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

3-5days

$76.00

Visible after login

- +

2 mg

3-5days

$109.00

Visible after login

- +

5 mg

3-5days

$156.00

Visible after login

- +

10 mg

3-5days

$216.00

Visible after login

- +

25 mg

3-5days

$376.00

Visible after login

- +

50 mg

3-5days

$586.00

Visible after login

- +

Product Overview

Product Name	A-1155463
CAS	1235034-55-5
Formula	C35H32FN5O4S2
MW	669.79
Appearance	Off-white to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).

Related literature

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.

PMID: 25787766 DOI: 10.1126/scitranslmed.aaa4642

Genomic analysis and selective small molecule inhibition identifies BCL-X(L) as a critical survival factor in a subset of colorectal cancer.

PMID: 26134786 PMCID: PMC4487849 DOI: 10.1186/s12943-015-0397-y

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.

PMID: 25313317 PMCID: PMC4190639 DOI: 10.1021/ml5001867

Sorry, no related items

History