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Sivelestat | EI546 | LY544349 | ONO5046

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Catalog No：CL1815 CAS No.：127373-66-4 MDLNo： Formula：C20H22N2O7S MW：434.46

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Product Overview

Product Name	Sivelestat \| EI546 \| LY544349 \| ONO5046
CAS	127373-66-4
Formula	C20H22N2O7S
MW	434.46
Appearance	White to off-white powder
Storage condition	4°C, protect from light

Product details

Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC₅₀ of 44 nM and a K_i of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

Related literature

A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats.

PMID: 17203197

Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder.

PMID: 18165924 DOI: 10.1007/s11010-007-9698-9

Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

PMID: 32860252 DOI: 10.1111/jcpt.13251