Sivelestat Sodium Anhydrous | ONO5046-Na | Sodium sivelestat | EI546 sodium | LY544349 sodium | 西维来司钠

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Sivelestat Sodium Anhydrous \| ONO5046-Na \| Sodium sivelestat \| EI546 sodium \| LY544349 sodium
CAS	150374-95-1
Formula	C20H21N2NaO7S
MW	456.44
Appearance	White to off-white powder
Storage condition	4°C, sealed storage, away from moisture

Product details

Sivelestat (EI546) sodium is a competitive inhibitor of human neutrophil elastase, with an IC₅₀ of 44 nM and a K_i of 200 nM. Sivelestat (EI546) sodium has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

Related literature

ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun.

PMID: 2049103 DOI: 10.1016/0006-291x(91)91862-7

Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder.

PMID: 18165924 DOI: 10.1007/s11010-007-9698-9

Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

PMID: 32860252 DOI: 10.1111/jcpt.13251