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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
10 mg	3-5 days	$78.00	Visible after login	- +
25 mg	3-5 days	$126.00	Visible after login	- +
50 mg	3-5 days	$196.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

10 mg

3-5 days

$78.00

Visible after login

- +

25 mg

3-5 days

$126.00

Visible after login

- +

50 mg

3-5 days

$196.00

Visible after login

- +

Product Overview

Product Name	Tanespimycin (Synonyms: 17-AAG; NSC 330507; CP 127374;KOS-953; KOS 953)
CAS	75747-14-7
Formula	C31H43N3O8
MW	585.69
MDL	MFCD04973892
Appearance	Purple to purplish red powder
Storage condition	4°C, protect from ligh

Product details

Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy.

Related literature

The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition. Eur J Cancer.

PMID: 23886587 DOI: 10.1016/j.ejca.2013.06.034

The heat shock protein 90 inhibitor 17-AAG suppresses growth and induces apoptosis in human cholangiocarcinoma cells.

PMID: 22955701 DOI: 10.1007/s10238-012-0208-3

HSP90 Inhibitor 17-AAG Selectively Eradicates Lymphoma Stem Cells.

PMID: 22751135 PMCID: PMC3443561 DOI: 10.1158/0008-5472.CAN-11-3600

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History

CL1950

Tanespimycin (Synonyms: 17-AAG; NSC 330507; CP 127374;KOS-953; KOS 953)

75747-14-7 98+%