Gemcitabine Hydrochloride | Gemcitabine HCl | LY 188011 hydrochloride | NSC 613327 HCl

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
250 mg	In-stock	$260.00	Visible after login	- +
500 mg	In-stock	$400.00	Visible after login	- +
1 g	In-stock	$750.00	Visible after login	- +
5 g	In-stock	$3100.00	Visible after login	- +

Product Overview

Product Name	Gemcitabine Hydrochloride (Synonyms: Gemcitabine HCl; LY 188011 hydrochloride;NSC 613327 HCl)
CAS	122111-03-9
Formula	C₉H₁₂ClF₂N₃O₄
MW	299.66
Appearance	White to off-white powder
Storage condition	4°C, sealed storage, away from moisture and light

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Product details

Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 and gemcitabine elaidate and a prodrug form of gemcitabine di- and triphosphates. Gemcitabine is phosphorylated by intracellular kinases to the intermediate metabolite gemcitabine monophosphate and the active di- and triphosphate forms.It is cytotoxic to HepG2 hepatocellular carcinoma and A549 non-small cell lung cancer (NSCLC) cells (IC50s = 5.2 and 16 nM, respectively) and inhibits tumor growth in various breast, colon, lung, and pancreatic cancer mouse xenograft models. Gemcitabine (12 mg/kg) sensitizes tumors to antibodies targeting programmed cell death protein 1 (PD-1), decreases the number of tumor-infiltrating regulatory T cells (Tregs), and increases survival in an MC-38 syngeneic mouse model of colon carcinoma. Formulations containing gemcitabine have been used in the treatment of cancer.
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CL1996

Gemcitabine (Synonyms: LY 188011;Gemcitabine Base;NSC 613327)

95058-81-4 98+%

History

CL1996A

Gemcitabine Hydrochloride (Synonyms: Gemcitabine HCl; LY 188011 hydrochloride;NSC 613327 HCl)

122111-03-9 98+%

Gemcitabine Hydrochloride (Synonyms: Gemcitabine HCl; LY 188011 hydrochloride;NSC 613327 HCl)

Chemical safety data sheet(MSDS)

Certificate Of Authenticity(CPA)