Gemcitabine Base | LY 188011 | NSC 613327 | CAS 95058-81-4

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
500 mg	In-stock	$146.00	Visible after login	- +
1 g	In-stock	$216.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

500 mg

In-stock

$146.00

Visible after login

- +

1 g

In-stock

$216.00

Visible after login

- +

Product Overview

Product Name	Gemcitabine Base \| LY 188011 \| NSC 613327
CAS	95058-81-4
Formula	C9H11F2N3O4
MW	263.2
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Gemcitabine (formerly LY-188011, NSC-613327; LY188011, NSC613327; dFdC; dFdCyd; trade name: Gemzar), an approved antimetabolite anticancer drug, is a potent DNA synthesis inhibitor with potential antineoplastic activity. With IC50s of 50 nM, 40 nM, 18 nM, and 12 nM, respectively, it suppresses the growth of PANC1, MIAPaCa2, BxPC3, and Capan2 cells. Difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP) are the active metabolites of gemcitabine that are produced intracellularly. The deoxynucleotide pool available for DNA synthesis is reduced when dFdCDP inhibits ribonucleotide reductase.

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History

CL1996

Gemcitabine Base | LY 188011 | NSC 613327

95058-81-4 98+%