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Home > Category > Signaling Pathways > DNA Damage/DNA Repair > Nucleoside Antimetabolite/Analog > Gemcitabine (Synonyms: LY 188011;Gemcitabine Base;NSC 613327)

Gemcitabine (Synonyms: LY 188011;Gemcitabine Base;NSC 613327)

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Catalog No：CL1996 CAS No.：95058-81-4 MDLNo：MFCD00869720 Formula：C9H11F2N3O4 MW：263.2
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Product Overview
Product Name Gemcitabine (Synonyms: LY 188011;Gemcitabine Base;NSC 613327)
CAS95058-81-4
FormulaC9H11F2N3O4
MW263.2
MDLMFCD00869720
AppearanceWhite to off-white powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Product details

Gemcitabine (formerly LY-188011, NSC-613327; LY188011, NSC613327; dFdC; dFdCyd; trade name: Gemzar), an approved antimetabolite anticancer drug, is a potent DNA synthesis inhibitor with potential antineoplastic activity. With IC50s of 50 nM, 40 nM, 18 nM, and 12 nM, respectively, it suppresses the growth of PANC1, MIAPaCa2, BxPC3, and Capan2 cells. Difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP) are the active metabolites of gemcitabine that are produced intracellularly. The deoxynucleotide pool available for DNA synthesis is reduced when dFdCDP inhibits ribonucleotide reductase.
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