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Pexidartinib (Synonyms: PLX-3397)

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Catalog No:CL2349 CAS No.:1029044-16-3 MDLNo: Formula:C20H15ClF3N5 MW:417.81
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Product Overview
Product Name Pexidartinib (Synonyms: PLX-3397)
CAS1029044-16-3
FormulaC20H15ClF3N5
MW417.81
Product details

Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity.

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