Apatinib Mesylate

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	$148.00	Visible after login	- +
5 mg	3-5days	$288.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

3-5days

$148.00

Visible after login

- +

5 mg

3-5days

$288.00

Visible after login

- +

Product Overview

Product Name	Apatinib Mesylate
CAS	1218779-75-9
Formula	C24H23N5O · CH4O3S
MW	493.58 \| 397.48(free)

Product details

Apatinib mesylate (YN968D1, Rivoceranib) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib mesylate induces both autophagy and apoptosis.

Related literature

YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo.

PMID: 21443688 PMCID: PMC11158267 DOI: 10.1111/j.1349-7006.2011.01939.x

Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters.

PMID: 20876799 PMCID: PMC2969180 DOI: 10.1158/0008-5472.CAN-10-0111

Apatinib (YN968D1) enhances the efficacy of conventional chemotherapeutical drugs in side population cells and ABCB1-overexpressing leukemia cells.

PMID: 22212563 DOI: 10.1016/j.bcp.2011.12.007

CL2507

Apatinib | Apatinib Free base | YN968D1| Rivoceranib

History

Chemical safety data sheet(MSDS)