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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	In-stock	$60.00	Visible after login	- +
10 mg	In-stock	$88.00	Visible after login	- +
25 mg	In-stock	$156.00	Visible after login	- +
50 mg	In-stock	$236.00	Visible after login	- +

Size

Availability

Price(USD)

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Quantity

5 mg

In-stock

$60.00

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- +

10 mg

In-stock

$88.00

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- +

25 mg

In-stock

$156.00

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- +

50 mg

In-stock

$236.00

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- +

Product Overview

Product Name	Carfilzomib (Synonyms: PR-171)
CAS	868540-17-4
Formula	C40H57N5O7
MW	719.91
MDL	MFCD11040997
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.
This product is unstable in solution state. We recommend that you use it immediately.

Related literature

Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma.

PMID: 17591945 PMCID: PMC2200918 DOI: 10.1182/blood-2007-01-065888

In vitro and in vivo therapeutic efficacy of carfilzomib in mantle cell lymphoma: targeting the immunoproteasome.

PMID: 23990113 DOI: 10.1158/1535-7163.MCT-13-0156

Carfilzomib is an effective anticancer agent in anaplastic thyroid cancer.

PMID: 25972243 DOI: 10.1530/ERC-14-0510

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