U0126 (Synonyms: MEK1/2抑制剂 )CAS :109511-58-2

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Product Overview

Product Name	U0126 (Synonyms: MEK1/2抑制剂 )
CAS	109511-58-2
Formula	C18H16N6S2
MW	380.49
MDL	MFCD11046040
Appearance	Off-white to light yellow powder
Storage condition	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

Product details

U-0126, also known as Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile, is a potent and selective MEK inhibitor with IC50 values of 72 nM for MEK1 and 58 nM for MEK2. It effectively inhibits AP-1 transcription activity and is known to block the production of inflammatory cytokines and matrix metalloproteinases. U0126 is an autophagy and mitophagy inhibitor.

Related literature

U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats.

PMID: 25492115 PMCID: PMC4348385 DOI: 10.1038/jcbfm.2014.217

Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo.

PMID: 21854809 DOI: 10.1016/j.antiviral.2011.08.002

RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo.

PMID: 18521085 DOI: 10.1038/onc.2008.163

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History

CL3111

U0126 (Synonyms: MEK1/2抑制剂 )

109511-58-2 98+%