Resibufogenin | Bufogenin | Recibufogenin | 465-39-4 | 酯蟾毒配基 | 蟾力苏蟾力苏

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Price(USD)

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Quantity

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Product Overview

Product Name	Resibufogenin \| Bufogenin \| Recibufogenin
CAS	465-39-4
Formula	C24H32O4
MW	384.51
Appearance	White to off-white powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.

Related literature

Resibufogenin administration prevents oxidative stress in a rat model of human preeclampsia.

PMID: 21174582 DOI: 10.3109/10641955.2010.525275

Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells.

PMID: 26121043 PMCID: PMC4488249 DOI: 10.1371/journal.pone.0129851

Effects of resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons.

PMID: 21763753 DOI: 10.1016/j.neulet.2011.06.059

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History

HL1716

Resibufogenin | Bufogenin | Recibufogenin

465-39-4 98+%

Resibufogenin | Bufogenin | Recibufogenin

Chemical safety data sheet(MSDS)