Resatorvid | TAK-242 | CLI-095 | CAS 243984-11-4

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5 mg	3-5days	$200.00	Visible after login	- +
10 mg	3-5days	$286.00	Visible after login	- +

Product Overview

Product Name	(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate;Resatorvid (Synonyms:TAK-242; CLI-095)
CAS	243984-11-4
Formula	C15H17ClFNO4S
MW	361.82
Appearance	Off-white to yellow solid
Storage condition	Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

Security information

Product details

Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.

Related literature

The anticancer effect of the TLR4 inhibition using TAK-242 (resatorvid) either as a single agent or in combination with chemotherapy: A novel therapeutic potential for breast cancer.

PMID: 31535397 DOI: 10.1002/jcb.29397

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate;Resatorvid (Synonyms:TAK-242; CLI-095)

Chemical safety data sheet(MSDS)

Certificate Of Authenticity(CPA)