Y-27632 |146986-50-7

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	In-stock	$106.00	Visible after login	- +
10 mg	In-stock	$200.00	Visible after login	- +
25 mg	In-stock	$348.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

5 mg

In-stock

$106.00

Visible after login

- +

10 mg

In-stock

$200.00

Visible after login

- +

25 mg

In-stock

$348.00

Visible after login

- +

Product Overview

Product Name	Y-27632 (free base)
CAS	146986-50-7
Formula	C14H21N3O
MW	247.34
Appearance	White to off-white powder
Storage condition	-20°C, protect from light, stored under nitrogen

Product details

Y-27632 is a potent and selective inhibitor of ROCK1 (p160ROCK) with IC50 of 140 nM in a cell-free assay, it exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
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Related literature

ROCK inhibitor primes human induced pluripotent stem cells to selectively differentiate towardsmesendodermal lineage via epithelial-mesenchymal transition-like modulation.

PMID: 27591478 DOI: 10.1016/j.scr.2016.07.009

Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.

PMID: 10779382

Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of adult human adipose tissue-derived stem cells

PMID: 22964332