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SB-431542

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Catalog No：CL1082 CAS No.：301836-41-9 MDLNo： Formula：C22H16N4O3 MW：384.39

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
10 mg	In-stock	$300.00	Visible after login	- +
20 mg	In-stock	$400.00	Visible after login	- +
50 mg	In-stock	$950.00	Visible after login	- +

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Product Overview

Product Name	SB-431542
CAS	301836-41-9
Formula	C22H16N4O3
MW	384.39
Appearance	white to off-white solid powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

SB-431542 is a novel small molecule inhibitor of the type I TGF-beta receptor, on a panel of human malignant glioma cell lines. SB-431542 blocked the phosphorylation and nuclear translocation of the SMADs, intracellular mediators of TGF-beta signaling, with decreased TGF-beta-mediated transcription. Furthermore, SB-431542 inhibited the expression of two critical effectors of TGF-beta-vascular endothelial growth factor and plasminogen activator inhibitor-1.

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CL1082

SB-431542

301836-41-9 98+%