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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
20 mg	In-stock	$500.00	Visible after login	- +
50 mg	In-stock	$550.00	Visible after login	- +
100 mg	In-stock	$800.00	Visible after login	- +

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20 mg

In-stock

$500.00

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50 mg

In-stock

$550.00

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- +

100 mg

In-stock

$800.00

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Product Overview

Product Name	GSK2606414 (Synonyms: GSK 2606414)
CAS	1337531-36-8
Formula	C24H20F3N5O
MW	451.44
Appearance	White powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

GSK2606414 is an orally available, selective protein kinase R-like ER kinase (PERK) inhibitor with an IC₅₀ value of 0.4 nM. It can inhibit thapsigargin-induced PERK phosphorylation in lung carcinoma A549 cells and attenuates subcutaneous pancreatic human tumor xenograft growth in mice. Because PERK mediates the unfolded protein response pathway, which has roles in neurotoxicity and cancer, inhibition of PERK signaling has potential applications for the treatment of cancer and also cognitive degeneration.
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History

CL1098

GSK2606414 (Synonyms: GSK 2606414)

1337531-36-8 98+%