Tofacitinib | Tasocitinib | CP-690550 | CAS 477600-75-2

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
20 mg	In-stock	$66.00	Visible after login	- +
50 mg	In-stock	$88.00	Visible after login	- +
100 mg	In-stock	$156.00	Visible after login	- +

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20 mg

In-stock

$66.00

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50 mg

In-stock

$88.00

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100 mg

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$156.00

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Product Overview

Product Name	Tofacitinib (Synonyms: Tasocitinib; CP-690550; 托法替尼; 托法替布)
CAS	477600-75-2
Formula	C16H20N6O
MW	312.37
MDL	MFCD11035919
Appearance	White or off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Tofacitinib is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.

Related literature

Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS.

PMID: 28087469 DOI: 10.1016/j.pupt.2017.01.002

JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production.

PMID: 22899318 DOI: 10.1002/art.34649

Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts.

PMID: 24890727 PMCID: PMC4106678 DOI: 10.4049/jimmunol.1400063

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History

CL1120

Tofacitinib (Synonyms: Tasocitinib; CP-690550; 托法替尼; 托法替布)

477600-75-2 98+%