Home > Category > Signaling Pathways > Immunology & Inflammation > Reactive Oxygen Species > (1′R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one;Trabectedin (Synonyms: Ecteinascidin 743; ET-743)

(1′R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one;Trabectedin (Synonyms: Ecteinascidin 743; ET-743)

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Catalog No：CL1372 CAS No.：114899-77-3 MDLNo： Formula：C39H43N3O11S MW：761.84

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	$266.00	Visible after login	- +
5 mg	3-5days	$518.00	Visible after login	- +

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Product Overview

Product Name	(1′R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one;Trabectedin (Synonyms: Ecteinascidin 743; ET-743)
CAS	114899-77-3
Formula	C39H43N3O11S
MW	761.84
Appearance	White to light yellow powder
Storage condition	-20°C, protect from light, stored under nitrogen

Product details

Trabectedin (Ecteinascidin 743; ET-743) is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has the potential for soft tissue sarcoma and ovarian cancer research.

Related literature

A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett.

PMID: 23792433 DOI: 10.1016/j.toxlet.2013.06.213

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Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and NSC 125973 in human breast cancer cell linesin vitro and in vivo.

PMID: 12460906

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Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells.

PMID: 20215499 DOI: 10.1158/0008-5472.CAN-09-2335

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(1′R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one;Trabectedin (Synonyms: Ecteinascidin 743; ET-743)

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