LDN-212854 | BMP Inhibitor III | LDN 212854 | 5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

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Availability

Price(USD)

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Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	LDN-212854 \| BMP Inhibitor III \| LDN 212854 \| 5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
CAS	1432597-26-6
Formula	C25H22N6
MW	406.48
Appearance	Light yellow to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

LDN-212854 is a bone morphogenetic protein (BMP) inhibitor that potently inhibits ALK2 (IC₅₀: 1.3 nM). LDN-212854 also inhibits ALK1 (IC₅₀: 2.40 nM). LDN-212854 can be used in the research of fibrodysplasia ossificans progressive and cancers, such as hepatocellular carcinoma (HCC).

Related literature

Development of an ALK2-biased BMP type I receptor kinase inhibitor.

PMID: 23547776 PMCID: PMC3901569 DOI: 10.1021/cb300655w

BMP9-ID1 signaling promotes EpCAM-positive cancer stem cell properties in hepatocellular carcinoma.

PMID: 33834612 PMCID: PMC8333780 DOI: 10.1002/1878-0261.12963

Sorry, no related items

History

CL1556

LDN-212854 | BMP Inhibitor III | LDN 212854 | 5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

1432597-26-6 98+%

LDN-212854 | BMP Inhibitor III | LDN 212854 | 5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

Chemical safety data sheet(MSDS)

Certificate Of Authenticity(CPA)