Vandetanib (ZD6474) | 443913-73-3

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
25 mg	In-stock	$300.00	Visible after login	- +
50 mg	In-stock	$400.00	Visible after login	- +
100 mg	In-stock	$500.00	Visible after login	- +
250 mg	In-stock	$900.00	Visible after login	- +
500 mg	In-stock	$1500.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

25 mg

In-stock

$300.00

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- +

50 mg

In-stock

$400.00

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- +

100 mg

In-stock

$500.00

Visible after login

- +

250 mg

In-stock

$900.00

Visible after login

- +

500 mg

In-stock

$1500.00

Visible after login

- +

Product Overview

Product Name	Vandetanib (Synonyms: ZD6474)
CAS	443913-73-3
Formula	C22H24BrFN4O2
MW	475.35
Appearance	White Powder

Product details

Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).
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