Pemetrexed disodium heptahydrate | LY231514 disodium heptahydrate | CAS 357166-29-1

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
500 mg	In-stock	$125.00	Visible after login	- +
1 g	In-stock	$200.00	Visible after login	- +
5 g	In-stock	$320.00	Visible after login	- +

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500 mg

In-stock

$125.00

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1 g

In-stock

$200.00

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5 g

In-stock

$320.00

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Product Overview

Product Name	Pemetrexed Disodium Heptahydrate (Synonyms: LY231514 disodium heptahydrate)
CAS	357166-29-1
Formula	C20H33N5Na2O13
MW	597.48
Appearance	White to off-white powder
Storage condition	4°C, sealed storage, away from moisture

Product details

Pemetrexed disodium heptahydrate (LY231514; HSDB7316; LY-231514; HSDB-7316; Alimta), the heptahydrated disodium salt of Pemetrexed and a pyrimidine-based antifolate, is an antifolate and antimetabolite anticancer medication. It targets TS, DHFR, and GARFT with Ki values of 1.3 nM, 7.2 nM, and 65 nM, in that order. In a variety of tumor types, including malignant mesothelioma, NSCLC (non-small cell lung carcinoma), carcinomas of the breast, colorectum, uterine cervix, head and neck, and bladder, pemetrexed shows strong antitumor activity.
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Related literature

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.

PMID: 9067281

Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma.

PMID: 20548032 DOI: 10.4049/jimmunol.0900437

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