| Product Name | Upadacitinib hemihydrate | 
|---|---|
| CAS | 2050057-56-0 | 
| Formula | C34H40F6N12O3 | 
| MW | 778.75 | 
| Size | Availability | Price(USD) | VIP Price (USD) | Quantity | |
|---|---|---|---|---|---|
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| Product Name | Upadacitinib hemihydrate | 
|---|---|
| CAS | 2050057-56-0 | 
| Formula | C34H40F6N12O3 | 
| MW | 778.75 | 
Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.