Secalciferol | (24R)-24,25-Dihydroxyvitamin D3

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Product Overview

Product Name	Secalciferol (Synonyms: (24R)-24,25-Dihydroxyvitamin D3)
CAS	55721-11-4
Formula	C₂₇H₄₄O₃
MW	416.64
MDL	MFCD00941417
Appearance	White to off-white powder
Storage condition	-20°C, protect from light, stored under nitrogen

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Product details

Secalciferol, also known as (24R)-24,25-Dihydroxyvitamin D3, is the primary active form of Vitamin D. This compound potently activates the vitamin D receptor (VDR) with an EC50 value of 150 nM. It plays a crucial role in various biological processes, including the regulation of calcium homeostasis, cellular differentiation, and proliferation. Additionally, Secalciferol has significant implications for the immune system, making it a promising area of research for conditions such as rickets, osteomalacia, hypercalcemia, and autoimmune disorders.

Related literature

Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24[J].

PMID: 27327272 DOI: 10.1021/acs.chemrestox.6b00170