Eltrombopag | Eltrombopag Free Base

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
10 mg	In-stock	$138.00	Visible after login	- +
25 mg	In-stock	$220.00	Visible after login	- +
50 mg	In-stock	$352.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

10 mg

In-stock

$138.00

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- +

25 mg

In-stock

$220.00

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- +

50 mg

In-stock

$352.00

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- +

Product Overview

Product Name	Eltrombopag (Synonyms: Eltrombopag Free Base; SB-497115)
CAS	496775-61-2
Formula	C25H22N4O4
MW	442.47
Appearance	Yellow to orange powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Eltrombopag (formerly SB-497115; SB 497115; SB497115), a member of the biarylhydrazone class, is a novel nonpeptide agonist of the thrombopoietin receptor (TpoR) approved for use in the treatment of chronic hepatitis C-associated thrombocytopenia and chronic immune (idiopathic) thrombocytopenia (ITP). Eltrombopag demonstrates an EC50 of 0.27 μM in murine BAF3 cells transfected with the luciferase reporter gene under direction of the STAT-activated IRF-1 promoter and human TpoR. Eltrombopag activates the receptor by association with metal ions (i.e., Zn2+) and specific amino acids within the transmembrane and juxtamembrane domains of the TpoR.
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