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Oclacitinib Maleate (Synonyms: Oclacitinib monomaleate; PF-03394197 monomaleate;PF-03394197 Maleate)

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Catalog No:CL2531 CAS No.:1640292-55-2 MDLNo: Formula:C19H27N5O6S MW:453.51
Size Availability Price(USD) VIP Price (USD) Quantity
5 mg 3-5days $163.00 Visible after login
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10 mg 3-5days $240.00 Visible after login
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25 mg 3-5days $450.00 Visible after login
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Product Overview
Product Name Oclacitinib Maleate (Synonyms: Oclacitinib monomaleate; PF-03394197 monomaleate;PF-03394197 Maleate)
CAS1640292-55-2
FormulaC19H27N5O6S
MW453.51
AppearanceWhite to off-white powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Product details

Oclacitinib maleate (formerly PF-03394197 maleate) is a novel and potent inhibitor of JAK (Janus kinase) family members with IC50 values ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM. Oclacitinib did not inhibit a panel of 38 non-JAK kinases and is the most potent at inhibiting JAK1. Oclacitinib also inhibits the function of JAK1-dependent cytokines involved in allergy and inflammation as well as pruritus. Cclacitinib is a targeted therapy that selectively inhibits JAK1-dependent cytokines involved in allergy, inflammation, and pruritus and suggests these are the mechanisms by which oclacitinib effectively controls clinical signs associated with allergic skin disease in dogs.
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