ZYF0033 | HPK1-IN-22

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	$188.00	Visible after login	- +
5 mg	3-5days	$466.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

3-5days

$188.00

Visible after login

- +

5 mg

3-5days

$466.00

Visible after login

- +

Product Overview

Product Name	ZYF0033 \| HPK1-IN-22
CAS	2380300-79-6
Formula	C26H30N4O2S
MW	462.61
Appearance	White to off-white powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

HPK1-IN-22 (compound ZYF0033) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 less than 10 nM based on the phosphorylation inhibition of MBP protein. HPK1-IN-22 decreases the phosphorylation of SLP76 (serine 376). HPK1-IN-22 promotes anticancer immune responses.HPK1-IN-22 inhibits tumor growth and caused increases intratumoral infiltration of DCs, NK cells, and CD107a+CD8+ T cells but decreased infiltration of regulatory T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells, and LAG3+CD8+ T cells in the 4T-1 syngeneic mouse model.

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History

CL2817

ZYF0033 | HPK1-IN-22

2380300-79-6 98+%

ZYF0033 | HPK1-IN-22

Chemical safety data sheet(MSDS)