210644-62-5 | (Z)-Orantinib | (Z)-SU6668

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Size

Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	(Z)-Orantinib \| (Z)-SU6668 \| (Z)-TSU-68
CAS	210644-62-5
Formula	C18H18N2O3
MW	310.35
Appearance	Orange to red powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

(Z)-Orantinib ((Z)-SU6668) is a potent, selective, orally active and ATP competitive inhibitor of Flk‐1/KDR, PDGFRβ, and FGFR1, with IC 50 s of 2.1, 0.008, and 1.2 μM, respectively. (Z)-Orantinib is a potent antiangiogenic and antitumor agent that induces established tumor regression.

Related literature

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors

PMID: 10945623

SU6668 inhibits Flk-1/KDR and PDGFRbeta in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in mice.

PMID: 10945623