23604-59-5 | TMC 435350 | 司美匹韦 | Simeprevir | TMC435

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
2 mg	3-5days	$108.00	Visible after login	- +
5 mg	3-5days	$168.00	Visible after login	- +
10 mg	3-5days	$266.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

2 mg

3-5days

$108.00

Visible after login

- +

5 mg

3-5days

$168.00

Visible after login

- +

10 mg

3-5days

$266.00

Visible after login

- +

Product Overview

Product Name	Simeprevir \| TMC435 \| HSDB 8227
CAS	923604-59-5
Formula	C38H47N5O7S2
MW	749.94
Appearance	White to off-white powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses.

Related literature

Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir

PMID: 34075346 PMCID: PMC8056950 DOI: 10.1021/acscentsci.0c01186

Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

PMID: 18678486 DOI: 10.1016/j.bmcl.2008.07.088

In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor.Antimicrob Agents Chemother

PMID: 19171797 PMCID: PMC2663092 DOI: 10.1128/AAC.01058-08